BEEM Journal Catalog
Volume 6 (2021)
Issue 604 (April 2021)
Issue 603 (March 2021)
What is the effect of prednisolone in preschool children with wheeze associated with acute respiratory illness?
Is low-dose ketamine as effective and safe as morphine for analgesia in the emergency department?
What is the risk of overcorrection of symptomatic hyponatremia with rapid intermittent bolus (RIB) versus slow continuous infusion (SCI) of hypertonic saline?
Can application of the YEARS algorithm safely exclude pulmonary embolism?
Issue 602 (February 2021)
From a patient's perspective, are antibiotics "just as good as" surgery for appendicitis?
What is the safety profile of ceftriaxone in pediatric patients, as determined by the frequency and type of adverse drug reactions documented in the published literature?
What are the latest guidelines for the diagnosis of acute aortic syndrome?
Does tranexamic acid reduce mortality from acute traumatic brain injury?
Issue 601 (January 2021)
Is a single troponin measurement below the level of detection superior to serial troponin measurements for the safe discharge of chest pain patients?
How does chest ultrasonography compare to supine chest radiography for the diagnosis of pneumothorax in trauma patients?
Is intranasal ketamine effective for the treatment of acute pain in children?
How do NSAIDs compare with other oral analgesics for treating acute soft tissue injuries?
Volume 5 (2020)
Issue 512 (December 2020)
Which variables are most associated with potentially missed appendicitis in the emergency department?
What are the effects of a high-dose 24-h infusion of tranexamic acid on death and thromboembolic events in patients with acute gastrointestinal bleeding?
Do patients with severe COVID-19 benefit from the addition of dexamethasone to usual care?
Is antacid therapy alone more effective than combined with lidocaine in relieving epigastric pain?
Issue 511 (November 2020)
Are older adults taking direct oral anticoagulants at higher risk of hospital admission for hemorrhage with clarithromycin than with azithromycin?
Is the combination of ibuprofen and acetaminophen for pediatric pain superior to either analgesic alone?
Does the addition of ticagrelor to aspirin reduce the risk of ischemic events following mild acute ischemic stroke or high-risk transient ischemic attack?
What is the risk of cardiovascular death among adults within days of a dispensed azithromycin prescription?
Issue 510 (October 2020)
Which is the optimum second-line therapy for adults and children with benzodiazepine-refractory convulsive status epilepticus?
How do N95 respirators compare to medical masks for preventing viral respiratory infections in healthcare workers?
Does the addition of N-terminal pro–B-type natriuretic peptide measurement to the Canadian Syncope Risk Score improve the prediction of 30-day serious adverse events in emergency department patients presenting with syncope?
Is there an association between pain, opioid treatment, and delirium in older adults in the emergency department?
Issue 509 (September 2020)
Which antibiotics commonly prescribed for acute otitis media are associated most with adverse events?
Is first attempt at pediatric lumbar puncture more successful with ultrasound guidance?
Is the Canadian Syncope Risk Score a valid clinical prediction tool for use in the emergency department?
For cardioversion of atrial fibrillation, is a strategy of drug–shock more effective than a shock-only and does pad placement make a difference?
Issue 508 (August 2020)
What is the clinical impact of the Ottawa subarachnoid hemorrhage rule and the 6-hour-computed tomography rule on investigation rates?
Is repeated antibiotic exposure associated with an increased body mass index by 4.5 years old?
Is conservative treatment for primary spontaneous pneumothorax noninferior to interventional treatment?
Does surgical repair within 6 hours of hip fracture diagnosis decrease mortality and major adverse events?
Issue 507 (July 2020)
Which of the 4 published decision aids provides the highest sensitivity to rule-out myocardial infarction and major adverse cardiac events?
Does oxygen via high-flow nasal cannula improve symptom relief compared to conventional oxygen therapy in palliative patients presenting with acute hypoxemic respiratory failure?
What is the diagnostic utility of troponin testing in elderly patients with nonspecific complaints?
Does application of the Feverkidstool reduce antibiotic prescritions for children with respiratory infections?
Issue 506 (June 2020)
Does irrigation with 20 minutes of cool running water reduce the need for skin grafts in children with burns?
How frequently do emergency physician pediatric musculoskeletal radiograph interpretations differ from radiologist interpretations and lead to adverse events?
What are the potential benefits and harms of suturing mammalian bite wounds?
Is the time to recovery from influenza-like illness reduced by adding oseltamivir to usual care?
Issue 505 (May 2020)
Can pulmonary embolism be ruled out through a combination of clinical assessment and d-Dimer testing?
What are the latest guidelines for cardiopulmonary resuscitation following pediatric cardiac arrest?
Does antibiotic treatment of asymptomatic bacteriuria in pregnancy reduce the development of pyelonephritis and associated risk of low birthweight and preterm birth?
What are the latest guidelines for the early management of acute ischemic stroke?
Issue 504 (April 2020)
Are patients with atrial fibrillation discharged sooner after electrical or chemical cardioversion first?
Does induced hypothermia (33°C during the first 24 hours) improve neurologic outcomes in patients with cardiac arrest and non-shockable rhythm?
What are the latest recommendations for assessing adult patients with acute nontraumatic headache?
Is a 0/1-hour high-sensitivity cardiac troponin T protocol noninferior to a 0/3-hour protocol in ruling out acute coronary syndrome in emergency department patients?
Issue 503 (March 2020)
What are the effects of tranexamic acid on head injury-related death, disability and adverse events in patients with acute traumatic brain injury?
Does the addition of nonsteroidal anti-inflammatory drugs and codeine to paracetamol (acetaminophen) produce superior analgesia for acute musculoskeletal injuries?
Do ibuprofen doses greater than 400 mg provide more effective analgesia at 60 minutes?
Does C-Reactive Protein testing for chronic obstructive pulmonary disease exacerbations reduce antibiotic use without harm?
Issue 502 (February 2020)
Is the incidence of influenza less in healthcare personnel wearing N95 respirator masks than those wearing standard medical/surgical masks?
Is sodium polystyrene sulfonate use associated with a higher risk of serious adverse gastrointestinal events at 30 days?
Is penicillin V four times daily for five days as effective as three times daily for 10 days for group A streptococci pharyngotonsillitis?
What are the 2019 recommendations for the diagnosis and treatment of community-acquired pneumonia in adults?
Issue 501 (January 2020)
Does avoidance of antibiotic therapy for uncomplicated diverticulitis result in increased adverse outcomes in the longterm?
How well do specific electrocardiogram and high-sensitivity cardiac troponin criteria identify acute myocardial infarction in patients presenting with chest discomfort and a left bundle branch block?
What is the incidence of unrecognized delirium in emergency departments and its impact on resources, patient function, and cognition at 60 days?
Does buddy taping boxer’s fractures provide better functional outcome than plaster immobilization?
Volume 4 (2019)
Issue 412 (December 2019)
What are the factors associated with fever phobia in caregivers and healthcare providers?
Does thrombolysis benefit patients with favorable perfusion imaging 4.5–9 hours after stroke onset?
How well does the extended Focused Assessment with Sonography in Trauma (eFAST) exam detect pneumothoraces, pericardial effusions, and intra-abdominal free fluid in injured patients?
Are prednisolone and/or low-dose dexamethasone noninferior to standard-dose dexamethasone for croup?
Issue 411 (November 2019)
Is nasal compression with tranexamic acid superior to simple nasal compression and or Merocel packing for cessation of bleeding from anterior epistaxis?
Can ultrasonography detect pediatric elbow fractures?
Does dextrose in intravenous fluids benefit dehydrated children?
Can high-sensitivity troponin values at emergency department presentation help predict MI and 30-day outcomes?
Issue 410 (October 2019)
What is the safety and effectiveness of non-invasive positive pressure ventilation compared to standard medical care for acute cardiogenic pulmonary edema?
How effective is lithium compared to other treatments for acute mania?
What is the risk of thrombosis in non-surgical patients treated with systemic tranexamic acid?
Can a pregnancy-adapted algorithm safely avoid diagnostic imaging in pregnant women with suspected pulmonary embolism?
Is Tramadol safe and effective for the treatment of osteoarthritis?
Issue 409 (September 2019)
What is the diagnostic yield of computed tomography for patients presenting to the ED with syncope or patients hospitalized for syncope?
Does bedside dynamic ultrasonography increase successful peripheral intravenous access rates?
Is point-of-care ultrasound accurate for diagnosing shoulder dislocation compared to X-ray?
How is acute lower gastrointestinal bleeding best diagnosed and managed?
Which clinical findings best indicate a cardiac or non-cardiac cause of syncope?
Issue 408 (August 2019)
What proportion of syncopal episodes are caused by pulmonary embolism?
Is a wait-and-see approach noninferior to early cardioversion in achieving sinus rhythm 4 weeks after an emergency department visit for new-onset, symptomatic atrial fibrillation?
What are the relative risks of stroke and bleeding in patients with paroxysmal versus sustained (persistent or permanent) atrial fibrillation who take oral anticoagulants?
What is the accuracy of lung ultrasonography compared to X-ray for the diagnosis of cardiogenic pulmonary edema in patients presenting with dyspnea?
Issue 407 (July 2019)
What are the benefits and harms of intravenous maintenance fluids for children?
Does delayed antibiotic treatment for elderly patients with suspected urinary tract infection (UTI) increase severe adverse outcomes?
What are the benefits and harms of different types of immobilization for common distal radius fractures in children?
Does bag-mask ventilation decrease the low oxygen saturation during endotracheal Intubation?
Issue 406 (June 2019)
Does the HEART score predict major adverse cardiac events in emergency department chest pain patients?
Can patients with suspected opioid overdose be safely discharged 1-hour after naloxone administration?
Does early invasive coronary angiography and revascularization in patients with non-ST-segment elevation acute coronary syndrome within 12 hours of diagnosis reduce adverse outcomes?
Which antiarrhythmic drug therapy is best for pediatric shock-refractory ventricular fibrillation/pulseless ventricular tachycardia cardiac arrest?
Which physical findings best predict difficult endotracheal intubation?
Issue 405 (May 2019)
Does clopidogrel with aspirin compared to aspirin alone given in the first 24 hours after a high-risk transient ischemic attack or minor ischemic stroke reduce recurrent stroke and death?
Does premedication with midazolam or haloperidol of adults undergoing procedural sedation reduce ketamine-associated agitation?
Are intranasal ketamine and fentanyl similarly effective in the treatment of acute pediatric limb pain?
Which interventions are most effective for emergency contraception?
Do probiotics improve symptoms in children with acute moderate-to-severe gastroenteritis?
Issue 404 (April 2019)
Do antiarrhythmic drugs benefit patients with shockable cardiac arrest?
What are the frequency and associated short-term, adverse outcomes in high-risk patients of nonsteroidal anti-inflammatory drug prescriptions?
What are the benefits and risks of dual antiplatelet treatment for acute minor ischemic stroke or high risk transient ischemic attack?
Can acetaminophen reduce febrile seizure recurrences during the same fever episode?
Can point-of-care ultrasound more accurately identify the cricothyroid membrane in patients with poorly defined neck anatomy than external palpation?
Issue 403 (March 2019)
Do critically ill people in need of fluid resuscitation benefit more from colloids or crystalloids?
Is 72-hour survival in adults with out-of-hospital cardiac arrest greater with initial endotracheal intubation or laryngeal tube insertion?
In out-of-hospital cardiac arrest patients, does a supraglottic airway device improve favorable functional outcome at 30 days compared with endotracheal intubation?
Does the HEART Pathway identify patients at low risk of a major adverse cardiac event at 1-year without increasing health care utilization?
Do patients with uncomplicated acute rhinosinusitis benefit from antibiotic treatment?
Do antiarrhythmic drugs benefit patients with shockable cardiac arrest?
Issue 402 (February 2019)
Is bag-mask ventilation during out-of-hospital cardiorespiratory arrest noninferior to endotracheal intubation for favorable neurological outcome?
Is treatment of central venous thrombosis more effective and safer with low-molecular weight or unfractionated heparin?
Does the prehospital administration of thawed plasma reduce mortality in trauma patients at risk for hemorrhagic shock?
Is ketamine an effective alternative to parenteral opioids for the treatment of acute pain?
Does pelvic examination improve the diagnosis of sexually transmitted disease in young females?
Is epinephrine a safe and effective treatment for cardiac arrest?
How effective are glucocorticoids for the treatment of croup in children?
Does abscess incision and drainage with point-of-care ultrasonography reduce clinical failure?
Issue 401 (
Does use of a bougie improve first-attempt emergency intubation success in difficult airway patients?
Can computed tomographic pulmonary angiography safely exclude pulmonary embolism?
Which vasopressors are associated with the best outcomes for adults in cardiac arrest?
Can bedside airway examination screening tests detect difficult to manage airways in the presence of normal anatomy?
Do patients with low-risk pulmonary embolism discharged early on rivaroxaban require fewer hospitalization days compared to standard of care?
Do balanced crystalloids versus saline decrease the risk of adverse outcome events in noncritically ill adults?
Volume 3 (2018)
Issue 312 (December 2018)
Is there benefit of antibiotics following incision and drainage of uncomplicated skin abscesses?
How accurate is the urinalysis for urinary tract infections in febrile infants 60 days and younger?
Does oseltamivir within 48 hours of influenza symptom onset in children reduce the time to symptom resolution?
Does intravenous fluid infusion rate or composition affect neurologic outcomes in children with diabetic ketoacidosis?
Does slow infusion reduce the associated dysphoric side effects of ketamine?
Are Pigtail catheters as safe and effective as chest tubes for the initial treatment of pneumothorax?
Issue 311 (November 2018)
Does cross-checking cases with another physician reduce the emergency department adverse event rate?
Is QTc prolongation in poisoned patients associated with an increased risk of death?
Does application of the pulmonary embolism rule-out criteria rule result in an inferior rate of thromboembolic events over 3 months among very low-risk patients with suspected pulmonary embolism?
Does tamsulosin promote ureteral stone expulsion?
How accurate is chest ultrasonography for the diagnosis of pneumothorax and hemothorax in adult trauma patients?
Issue 310 (October 2018)
Do balanced crystalloids versus saline decrease the risk of adverse outcome events in critically ill adults?
Is honey an effective treatment for acute cough in children?
In acute ischemic stroke and high-risk transient ischemic attack patients, does the addition of clopidogrel to daily aspirin reduce the risk of major ischemic vascular events at 90 days?
Is trimethoprim for urinary tract infection associated with increased adverse events in the elderly?
Is there an association between fasting before procedural sedation and adverse events in children?
Issue 309 (September 2018)
Can antidotes be delivered via the intraosseous route?
Do systemic methicillin-resistant Staphylococcus aureus-active antibiotics improve cure rates following abscess incision and drainage?
What is the optimal treatment of superficial thrombophlebitis of the legs in relieving symptoms and preventing venous thromboembolism?
Are alpha-blockers effective as medical expulsive therapy for ureteral stones?
Issue 308 (August 2018)
What are the effects of nebulized hypertonic saline solution (≥ 3%) in reducing morbidity in children up to 24 months of age with acute bronchiolitis?
Is supplemental oxygen beneficial for normoxic patients with acute myocardial infarction?
In patients presenting to the emergency department with syncope, what is the prevalence of pulmonary embolism and venous thromboembolism at first evaluation and within 90 days?
Is high-velocity nasal insufflation less effective than noninvasive positive-pressure ventilation in the treatment of emergency department patients with respiratory failure?
How accurate is computed tomography in the diagnosis of intra-abdominal injuries in stable patients with anterior abdominal stab wounds?
How beneficial and safe Is liberal versus conservative supplemental oxygen for acutely ill adults?
Issue 307 (July 2018)
What is the epidemiology of bacteremia in febrile infants aged 60 days and younger?
Is the combination of an anti-inflammatory drug with an opioid more effective for musculoskeletal injury pain in children than either agent alone?
What is the comparative effectiveness of antiarrhythmics for out-of-hospital cardiac arrest for patients with refractory ventricular fibrillation?
Is topical tranexamic acid effective for anterior epistaxis in patients taking antiplatelet therapy?
Does early treatment with high-flow oxygen therapy in infants with bronchiolitis and hypoxemia reduce the escalation of care?
Issue 306 (June 2018)
Is morphine superior to ibuprofen for relieving children’s pain at home, after minor orthopedic surgery?
Does tamsulosin effectively and safely facilitate passage of large, distal ureteric stones?
What is the risk for emergency neurosurgery or death in children with isolated skull fractures?
Do intravenous sodium bicarbonate or sodium chloride with oral acetylcysteine or placebo prevent acute kidney injury and major adverse outcomes in high-risk patients undergoing angiography?
Is 2 days of dexamethasone for children with acute asthma less effective than 5 days of prednisone?
Issue 305 (May 2018)
Is point-of-care ultrasound during resuscitation associated with delays in chest compressions?
Are there benefits or harms in treating asymptomatic bacteriuria?
Can the Testicular Workup for Ischemia and Suspected Torsion score risk stratify pediatric males with acute scrotum?
Is the Broselow tape an accurate weight-estimation instrument and effective drug-dosing guide for pediatric emergencies?
Issue 304 (April 2018)
Does a combination of ibuprofen and acetaminophen provide similar pain reduction to a combination of acetaminophen and an opioid for emergency department patients with acute extremity pain?
Can symptoms and physical examination findings identify children with radiographic pneumonia?
Does apneic oxygenation increase the average lowest oxygen saturation during rapid sequence intubation?
Is Coronary CT angiography superior to standard-of-care for detecting atherosclerotic disease in patients with acute chest pain?
Issue 303 (March 2018)
In patients with suspected myocardial infarction without hypoxemia, what is the effect of routine oxygen therapy compared to ambient air on mortality?
Can complete blood cell counts accurately identify febrile infants with bacteremia or bacterial meningitis?
What are the benefits and harms of using corticosteroids as an adjunct treatment for sore throat?
How well does the Ottawa Subarachnoid Hemorrhage Rule detect or rule out subarachnoid hemorrhage?
Issue 302 (February 2018)
What is the risk of acute kidney injury, renal replacement therapy, and mortality after computed tomography with intravenous contrast compared with computed tomography without use of contrast?
Which medications are associated with adverse events in procedural sedation for children?
Does oral prednisolone reduce symptom duration and severity in nonasthmatic adults with acute lower respiratory tract infection?
How well does bivalve cast immobilization maintain reduction of pediatric displaced forearm fractures?
Issue 301 (January 2018)
Does focused assessment with sonography for trauma examination decrease the rate of abdominal computed tomography scans in hemodynamically stable pediatric patients with blunt torso trauma?
Does oxygen via nasal cannula during the apneic period of endotracheal intubation reduce hypoxemia?
Which is the most effective and least harmful method of reducing pulled (nursemaid’s) elbow?
Is haloperidol an effective single agent treatment for psychosis-induced aggression or agitation?
Volume 2 (2017)
Issue 212 (December 2017)
Is modified Valsalva maneuver more effective than the standard Valsalva maneuver in terminating paroxysmal supraventricular tachycardia?
Which compression-to-ventilation methods for cardiac arrest are associated with better outcomes?
Does nebulized 3% hypertonic saline treatment in the emergency department reduce the rate of hospital admissions among infants with a first episode of acute bronchiolitis?
Can high-flow nasal cannula oxygen reduce respiratory rate in patients with cariogenic pulmonary edema?
Issue 211 (November 2017)
Do critically ill adults requiring vasopressor support benefit from a higher target mean arterial pressure?
Do femoral nerve blocks reduce acute pain and use of opioids in elderly patients with hip fractures?
Does more rapid sepsis treatment reduce in-hospital mortality?
Does the addition of Trimethoprim-Sulfamethoxazole to Cephalexin improve the clinical cure of cellulitis?
Issue 210 (October 2017)
Does oral dexamethasone without antibiotic increase acute sore throat symptom resolution in adults?
Does early administration of tranexamic acid reduce death in women with post-partum hemorrhage?
What is the rate of traumatic intracranial hemorrhage from a ground-level fall in patients taking antithrombotic therapy?
Does procedural sedation with ketofol produce fewer recovery reactions than ketamine?
Issue 209 (September 2017)
Does early goal-directed therapy reduce mortality among patients with severe sepsis or septic shock?
Do intravenous first-line benzodiazepines terminate seizures faster than non-intravenous routes?
Does the Quick-Wee method facilitate faster clean catch urine collection in infants?
Does needle aspiration for spontaneous pneumothorax reduce hospital length-of-stay compared to chest tube drainage?
Which head injury decision rule for children is most accurate?
Issue 208 (August 2017)
Which clinical findings can best rule in/out acute appendicitis in children?
Do patients presenting to the emergency department with chest pain require cardiac monitoring?
How accurate is point-of-care focused echocardiography in predicting outcome of resuscitation in cardiac arrest patients?
Is ketamine an effective adjunct for acute pain in the emergency department?
Which early rule-out strategy for early rule-out acute myocardial infarction using high-sensitivity cardiac troponin I should be favored for clinical implementation in routine care?
Issue 207 (July 2017)
How effective is high-flow nasal cannula therapy at preventing endotracheal intubation in adults?
Do patients undergoing intravenous contrast-enhanced computed tomography experience increased incidence of acute kidney injury?
Is Ketamine effective at reducing pain over 120 minutes when used as an adjunct to opioid therapy?
Does the addition of diazepam to naproxen improve low back pain and improve functional outcomes?
Does emergency physician prescribing of opioids contribute to patient long-term opioid use?
Do patients treated in hospital for community-acquired pneumonia benefit from the addition of corticosteroid therapy?
Issue 206 (June 2017)
What are the most recent recommendations for management of carbon monoxide poisoning?
What is the comparative effectiveness of 10, 15, and 30 mg of intravenous ketorolac in reducing pain at 30 minutes in patients presenting to the emergency department acute pain?
How well do the European Society of Cardiology pathway and High-STEACS algorithm rule out acute myocardial infarction?
What is the accuracy of point-of-care ultrasound in diagnosing abscess in emergency department patients with skin and soft tissue infections compared to standard care?
Is there benefit to combining inhaled beta-agonist and anticholinergic agents for the emergency management of adults with asthma?
Issue 205 (May 2017)
Is it safe to rule out acute pulmonary embolism with stand-alone D-dimer testing below 750 µg/L?
Can patients with large ureteric stones benefit from treatment with alpha-blockers?
What is the effectiveness of shared decision-making facilitated by a decision aid in patients with low-risk chest pain?
Is therapeutic hypothermia beneficial for traumatic brain Injury in adult and pediatric patients?
How well does of point-of-care-ultrasound identify pediatric forearm fractures?
Issue 204 (April 2017)
What are the target hemoglobin levels for red blood cell transfusion among hemodynamically stable adult patients?
In older adults with a hip fracture, does a regional femoral nerve block in the emergency department followed by a continuous fascia iliaca block by anesthesiologist improve pain control and walking abilities?
Which is the most effective reduction maneuver for nursemaid’s elbow in toddlers?
What are the most recent recommendations for the management of antithrombotic-associated intracranial hemorrhage?
Issue 203 (March 2017)
What is the prevalence of pulmonary embolism among patients with acute exacerbations of chronic obstructive pulmonary disease?
What are the key recommendations for evaluation of adult patients with suspected transient ischemic attack in the emergency department?
In a meta-analysis of patients with a confirmed diagnosis of ureteral stone, is tamsulosin more effective than placebo in improving stone passage?
Is there benefit from percutaneous coronary intervention for post-arrest patients without ST-elevation myocardial infarction?
In patients with severe sepsis, does hydrocortisone prevent progression to septic shock?
What is the prevalence of pulmonary embolism in patients admitted to hospital for first-time syncope?
Issue 202 (February 2017)
Does a 1:1 ratio, mixed combination of propofol and ketamine result in fewer adverse respiratory events than propofol alone for adult patients requiring procedural sedation and analgesia?
Can a low concentration of high-sensitivity cardiac troponin T at emergency department presentation, combined with the history and electrocardiogram rule out major adverse cardiac events within 30 days?
In adult patients requiring urgent reversal of warfarin, do prothrombin complex concentrates and fresh frozen plasma result in different rates of all-cause mortality?
What is the efficacy of amiodarone on survival after cardiac arrest compared to lidocaine or placebo?
Issue 201 (January 2017)
Which patient characteristics and investigations are most accurate for diagnosing subarachnoid hemorrhage?
Are procainamide and amiodarone effective for terminating well-tolerated ventricular tachycardia?
Is video laryngoscopy superior to direct laryngoscopy for the endotracheal intubation of critically ill patients?
Is the “Step-by-Step” approach to manage young febrile infants effective?
Do corticosteroids improve recovery of facial motor function in patients with Bell’s palsy?
What are the effects of amiodarone on survival and neurological outcome after cardiac arrest?
Volume 1 (2016)
Issue 112 (December 2016)
Which is the most effective dose of intravenous ketamine for pediatric procedural sedation and analgesia in the emergency department?
How should emergency physicians manage infants with brief resolved unexplained events?
What are the benefits and harms of neuraminidase inhibitors for the prevention and treatment of influenza, and what was their impact on mortality during the 2009A/H1N1 influenza epidemic?
What is the relative efficacy of intensive versus standard antihypertensive treatment in patients with spontaneous supratentorial intracerebral hemorrhage?
What are the relative benefits and adverse effects of antibiotic therapy for otitis media with effusion aka “glue ear”?
Issue 111 (November 2016)
What are the risks and benefits of antiepileptic drug treatment for first unprovoked seizure?
What is the efficiency and failure rate of diagnostic strategies for ruling out pulmonary embolism?
Are pelvic circumferential compression devices safe and effective for the treatment of pelvic fractures?
Can antibiotics be used as first line therapy for uncomplicated acute appendicitis?
What are the early secondary prevention benefits of aspirin after transient ischemic attack or ischemic stroke?
Issue 110 (October 2016)
How should well-appearing children under 2 years old with fever be managed in the emergency department?
Which are the most diagnostic features of infectious mononucleosis?
Is a single oral dose of dexamethasone non-inferior to 5 days of oral prednisone in preventing asthma relapse?
Can children with mild gastroenteritis be as effectively treated with initial oral rehydration treatment using dilute apple juice compared to oral electrolyte maintenance solution?
Are alpha2-adrenergic agonists effective treatment for opioid withdrawal?
Issue 109 (September 2016)
What are the recommendations for antibiotic stewardship?
After minimizing heterogeneity in studies reporting the effectiveness of hypertonic saline in bronchiolitis, does hypertonic saline reduce hospital length-of-stay?
Does a deliberately restricted laryngeal view with the GlideScope® video laryngoscope facilitate tracheal intubation?
Is intra-arterial mechanical thrombectomy safe and effective in patients with ischemic stroke?
Is video laryngoscopy superior to direct laryngoscopy for the endotracheal intubation of cardiac arrest patients?
Issue 108 (August 2016)
Is diclofenac more effective at reducing pain from ureteric calculi than morphine or paracetamol?
Which nonsteroidal anti-inflammatory drugs are most effective for the treatment of arthritic pain?
Which benzodiazepine is most effective for the treatment of status epilepticus in children?
Is the wound infection cure rate greater with clindamycin than trimethoprim-sulfamethoxazole?
Does amiodarone or lidocaine improve survival to hospital discharge after out-of-hospital cardiac arrest due to shock-refractory ventricular fibrillation or pulseless ventricular tachycardia compared to placebo?
Issue 107 (July 2016)
Does the phosphodiesterase-5 inhibitor sildenafil facilitate passage of distal ureteric stones?
Can bedside sonographic measurement of optic nerve sheath diameter in the emergency department identify increased intracranial pressure?
Does antibiotic therapy for non-perforated appendicitis result in more complications compared with appendectomy?
Is early goal-directed therapy associated with lower mortality rates than usual care in patients with severe sepsis and septic shock?
Is a single-volar digital injection of local anesthetic as effective and less painful than a double-dorsal injection?
Issue 106 (June 2016)
What is the risk of a motor vehicle accident within 2 years of a first-time syncope?
Does treatment of uncomplicated drained abscesses with trimethoprim-sulfamethoxazole reduce the need for alternate antibiotic therapy or repeat surgical drainage 7–14 days after treatment?
Do prophylactic antibiotics reduce post-surgical infection for simple hand injuries?
Does inhaled magnesium sulfate benefit patients with moderate to severe acute asthma?
Can point-of-care testing for group A streptococci in patients presenting with pharyngitis improve appropriate antibiotic prescribing?
Issue 105 (May 2016)
What is the comparative effectiveness of vasopressors on mortality in patients with shock?
Which treatments are recommended for status epilepticus?
Is prednisone as effective as indomethacin for the treatment of acute gout?
Which are the best tests available to the emergency physician for diagnosing acute heart failure?
Can lung ultrasonography reduce chest X-ray use in children with suspected pneumonia?
Issue 104 (April 2016)
Does the volume of intravenous fluid administration influence the time to metabolic normalization in children with type 1 diabetes mellitus and diabetic ketoacidosis?
Does ketorolac nasal spray (NS) relieve acute migraine headaches as effectively as sumatriptan NS or placebo within 2 hours?
Which agents are most effective and safest for pediatric procedural sedation?
What are the latest recommendations for the management of venous thromboembolism?
Does targeted temperature management of successfully resuscitated cardiac arrest patients by conventional cooling methods improve neurologic outcome or survival?
Issue 103 (March 2016)
Can serial high-sensitivity cardiac troponin T measurement results 1 hour apart accurately diagnose acute myocardial infarction in the emergency department?
Can spontaneous subarachnoid hemorrhage be ruled out by modern-generation computed tomography scanning of the brain within 6 hours of acute headache onset?
What are the analgesic and side effects of ketamine-propofol combination (ketofol) in comparison with propofol in procedural sedation and analgesia?
Which imaging is most appropriate for emergency department patients with chest pain?
Issue 102 (February 2016)
Does inhaling isopropyl alcohol reduce nausea?
Is a delayed antibiotic prescription for acute uncomplicated respiratory tract infection less effective at reducing symptom burden than an immediate antibiotic prescription?
Does early coronary computed tomography angiography identify more adult emergency department patients requiring revascularization in 30 days than standard optimal care?
How well does oblique angle chest X-ray identify occult pneumothorax in trauma patients?
What are the most common and serious adverse reactions to oral corticosteroids?
Issue 101 (January 2016)
Is continuous positive airway pressure by helmet effective in the treatment of infants with bronchiolitis?
Does tamsulosin 0.4 mg daily facilitate passage of distal ureteric calculi ≤ 10 mm?
Does apneic oxygenation via nasal cannula increase the lowest arterial oxygen saturation experienced by patients undergoing endotracheal intubation?
Is a single dose of oral dexamethasone noninferior to 3 days of oral prednisolone in the treatment of pediatric asthma exacerbations?
Do patients with community-acquired pneumonia benefit from systemic corticosteroids?
Are forearm torus (buckle) fractures more effectively and safely treated with rigid or non-rigid immobilization?