Is the wound infection cure rate greater with clindamycin than trimethoprim-sulfamethoxazole?

BEEM Bottom Line

Why is this study important?

Emergency department (ED) visits for skin and soft tissue infection (SSTI) are increasing.[1] In patients treated for wound infections, the off-patent and relatively inexpensive antibiotics (Abx) clindamycin and trimethoprim-sulfamethoxazole (TMP-SMX) demonstrate similar treatment effectiveness and adverse events.

Which, if any, threats to validity are most likely to have an impact on the results and how?

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