Does premedication with midazolam or haloperidol of adults undergoing procedural sedation reduce ketamine-associated agitation?

BEEM Bottom Line

Why is this study important?

Ketamine is routinely used in emergency department (ED) procedural sedations for its favourable analgesic, sedative, and hemodynamic profiles. However, emergence reaction or ketamine-associated agitation (KAA) is reported to be as high as 20–25%.[1] [2] Prophylactic pre-sedation medication with midazolam or haloperidol might mitigate KAA.

Which, if any, threats to validity are most likely to have an impact on the results and how?

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