Does more rapid sepsis treatment reduce in-hospital mortality?

BEEM Bottom Line

Why is this study important?

Emergency department (ED) screening for septic patients is a common practice based on the assumption that the sepsis mortality rate increases with delay of care. However, the association between the timing of the components of sepsis care and optimum patient outcome has yet to be determined. This study seeks to identify which components of sepsis treatment have the greatest mortality benefit if given within 3 or 6 hours (h) of presentation.

Which, if any, threats to validity are most likely to have an impact on the results and how?

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