In patients with suspected myocardial infarction without hypoxemia, what is the effect of routine oxygen therapy compared to ambient air on mortality?

BEEM Bottom Line

Why is this study important?

Based on theoretical advantage and animal studies, routine oxygen (O2) has been recommended for patients with acute myocardial infarction (AMI) for years. However, this can easily lead to over oxygenation which, according to new evidence, can be harmful in ST-segment elevation myocardial infarction (STEMI). The effect of routine supplemental O2 on mortality is still unclear.

Which, if any, threats to validity are most likely to have an impact on the results and how?

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