Can high-flow nasal cannula oxygen reduce respiratory rate in patients with cariogenic pulmonary edema?

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Why is this study important?

Emergency department (ED) resource limitations can preclude timely noninvasive ventilation for patients with cariogenic pulmonary edema. This is especially true for those with only mild or moderate respiratory symptoms. This randomized controlled trial (RCT) examines whether high-flow nasal cannula (HFNC) oxygen (O2) therapy can reduce the severity of dyspnea during the first hour of treatment in ED patients with cardiogenic pulmonary edema compared to nasal cannula/non-rebreather mask (conventional O2 therapy).

Which, if any, threats to validity are most likely to have an impact on the results and how?

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