How well do the European Society of Cardiology pathway and High-STEACS algorithm rule out acute myocardial infarction?

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Why is this study important?

The optimum rule-out strategy for acute myocardial infarction (AMI) using high-sensitivity cardiac troponin (hs-cTn) measurements is yet to be determined. As the European Society of Cardiology (ESC) 0- and 3-hour (h) pathway using hs-cTn assays may fall below physicians’ expectations to safely rule-out AMI in the emergency department (ED), this study compares its performance to the High-Sensitivity Troponin in the Evaluation of Patients with Acute Coronary Syndrome (High-STEACS), an alternative pathway in the same population.

Which, if any, threats to validity are most likely to have an impact on the results and how?

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