Is the time to recovery from influenza-like illness reduced by adding oseltamivir to usual care?

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Why is this study important?

Clinical practice guidelines recommend that patients with confirmed or suspected influenza who have severe, complicated, or progressive illness; who require hospitalization; or, who are at high risk for influenza-associated complications should receive treatment as soon as possible with antiviral medications.[1] [2] It can also be considered for symptomatic outpatients with suspected influenza (i.e., influenza-like illness [ILI]), if initiated within 48 hours of symptom onset.[1] [2]  Oseltamivir has been shown to reduce time to symptom resolution.[3] This trial evaluated the effect of oseltamivir added to usual therapy on patient-reported time to return to usual daily activity.

Which, if any, threats to validity are most likely to have an impact on the results and how?

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