Does apneic oxygenation increase the average lowest oxygen saturation during rapid sequence intubation?

BEEM Bottom Line

Why is this study important?

The strength of the association between transient hypoxemia during rapid sequence intubation (RSI) and subsequent hypoxic encephalopathy is unknown.[1]  Apneic oxygenation (AO) with administration of high flow oxygen (≥ 15 L/min) via nasal cannula is largely supported by observational data. This is the first randomized controlled trial (RCT) in an emergency department (ED) setting to determine if apneic oxygenation prevents desaturation during RSI.

Which, if any, threats to validity are most likely to have an impact on the results and how?

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