Is a 0/1-hour high-sensitivity cardiac troponin T protocol noninferior to a 0/3-hour protocol in ruling out acute coronary syndrome in emergency department patients?

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Why is this study important?

The introduction of high-sensitivity cardiac troponin (hs-cTn) assays have allowed for much earlier serial cTn testing than ever before with more reliable results at lower concentrations. This Australian, multicenter trial sought to determine whether a 0/1-hour hs-cTnT protocol was noninferior to a 0/3-hour standard cTnT protocol in emergency department (ED) patients presenting with suspected acute coronary syndrome (ACS).

Which, if any, threats to validity are most likely to have an impact on the results and how?

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