Do intravenous sodium bicarbonate or sodium chloride with oral acetylcysteine or placebo prevent acute kidney injury and major adverse outcomes in high-risk patients undergoing angiography?

BEEM Bottom Line

Why is this study important?

Exposure to coronary angiography and iodinated contrast media specifically has been associated with acute kidney injury (AKI) and subsequent worsening of chronic kidney disease resulting in the need for hemodialysis and even death.[1][2] Trials of pre-administration of different agents to minimize these outcomes have yielded conflicting results.

Which, if any, threats to validity are most likely to have an impact on the results and how?

Thank you for your interest in the BEEM Journal!

To read the rest of this article or to access the entire collection of BEEM Critical Appraisals, please purchase a subscription at the link below.

If you would like a pre-view, click here to view some sample articles

Premium Content Available Through Subscription

BEEM is a knowledge translation project which aims to extract the most recent, EM relevant, and valid evidence from the volumes of available medical research and deliver it to EM practitioners in an easily consumable format to help guide their clinical practice. This valuable distilled information provided by BEEM is available through BEEM's accredited CME courses or through our online journal.

A BEEM Journal Subscription will provide you with unlimited access to our entire collection of Critical Appraisals for 1 year.