Does antibiotic therapy for non-perforated appendicitis result in more complications compared with appendectomy?
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Why is this study important?
While appendectomy has been standard care for acute uncomplicated appendicitis for many years, recent literature has questioned whether antibiotic (Abx) therapy may be a safer alternative. With recent studies as well as a breadth of outcome measures and patient populations, a pragmatic systematic review and meta-analysis was deemed important to answer this question.
Which, if any, threats to validity are most likely to have an impact on the results and how?
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