Does antibiotic therapy for non-perforated appendicitis result in more complications compared with appendectomy?

BEEM Bottom Line

Why is this study important?

While appendectomy has been standard care for acute uncomplicated appendicitis for many years, recent literature has questioned whether antibiotic (Abx) therapy may be a safer alternative. With recent studies as well as a breadth of outcome measures and patient populations, a pragmatic systematic review and meta-analysis was deemed important to answer this question.

Which, if any, threats to validity are most likely to have an impact on the results and how?

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