Is early goal-directed therapy associated with lower mortality rates than usual care in patients with severe sepsis and septic shock?

BEEM Bottom Line

Why is this study important?

Sepsis and septic shock are frequently encountered in the emergency department (ED), and appropriate management has a direct impact on mortality. This study indicates that the additional time and resources of early goal-directed therapy (EGDT) are not required for all patients presenting with sepsis and septic shock.

Which, if any, threats to validity are most likely to have an impact on the results and how?

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