What is the safety profile of ceftriaxone in pediatric patients, as determined by the frequency and type of adverse drug reactions documented in the published literature?

BEEM Bottom Line

Why is this study important?

As a third-generation cephalosporin, ceftriaxone is a broad-spectrum antibiotic that is used for a wide range of indications in the pediatric emergency department. However, despite its common use, the frequency and severity of associated adverse drug reactions (ADRs) has not been widely studied in pediatric patients.

Which, if any, threats to validity are most likely to have an impact on the results and how?

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