Is trimethoprim for urinary tract infection associated with increased adverse events in the elderly?

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Why is this study important?

The antibiotic (Abx) combination of trimethoprim and sulfamethoxazole (TMP-SMX) is commonly prescribed for urinary tract infections (UTI). TMP alone has been associated with acute hyperkalemia and the combination has been associated with fatal cardiac arrhythmias. This study evaluates the association of trimethoprim with adverse outcomes.

Which, if any, threats to validity are most likely to have an impact on the results and how?

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