What are the analgesic and side effects of ketamine-propofol combination (ketofol) in comparison with propofol in procedural sedation and analgesia?

BEEM Bottom Line

Why is this study important?

Procedural sedation and analgesia (PSA) is a core element of emergency medicine. Uncertainty persists regarding optimal drug combination and dosing in part because serious adverse events are rare.

Which, if any, threats to validity are most likely to have an impact on the results and how?

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