Does the volume of intravenous fluid administration influence the time to metabolic normalization in children with type 1 diabetes mellitus and diabetic ketoacidosis?

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Why is this study important?

A small previous adult study suggested that “more modest amounts of infused fluids in the first 4 hours of treatment resulted in a more rapid recovery of acid-base status and shorter hospital stay, which correlated with a reduction in medical costs.” The aim of this study was to determine whether the volume of fluid administration in children with diabetic ketoacidosis (DKA) similarly influences the rate of metabolic normalization.

Which, if any, threats to validity are most likely to have an impact on the results and how?

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