Does the prehospital administration of thawed plasma reduce mortality in trauma patients at risk for hemorrhagic shock?

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Why is this study important?

Treatment of hemorrhage shock currently favors the early administration of blood components to minimize the subsequent inflammatory responses and endothelial permeability, as well as the coagulopathy associated with high volumes of crystalloids.[1] Despite potential mortality benefit, plasma transfusion is associated with acute lung injury, circulatory overload, allergic and hemolytic reactions, and infection.[2] This is the first trial to determine if the civilian prehospital administration of thawed plasma can reduce trauma mortality without causing significant adverse effects.

Which, if any, threats to validity are most likely to have an impact on the results and how?

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