Does a 1:1 ratio, mixed combination of propofol and ketamine result in fewer adverse respiratory events than propofol alone for adult patients requiring procedural sedation and analgesia?

BEEM Bottom Line

Why is this study important?

Procedural sedation and analgesia (PSA) is commonly performed in the emergency department (ED) to aid with painful procedures. The use of Ketofol (combination of intravenous [IV] ketamine and propofol) gained popularity because it is thought that this combination decreases the rate of adverse events when compared to the use of propofol alone. This is the largest multicenter, randomized controlled trial (RCT) that compared the rate of adverse events of ketofol to propofol after 2 smaller single center RCTs.

Which, if any, threats to validity are most likely to have an impact on the results and how?

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