In acute ischemic stroke and high-risk transient ischemic attack patients, does the addition of clopidogrel to daily aspirin reduce the risk of major ischemic vascular events at 90 days?
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Why is this study important?
Following an ischemic stroke or transient ischemic attack (TIA), there is increased risk of a subsequent stroke. This risk can be mitigated with antiplatelet therapy, but at the increased risk of bleeding. This is the largest trial to date assessing the effectiveness and safety of combined clopidogrel and aspirin (ASA) in minor ischemic stroke or high-risk TIA patients.
Which, if any, threats to validity are most likely to have an impact on the results and how?
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