Is Coronary CT angiography superior to standard-of-care for detecting atherosclerotic disease in patients with acute chest pain?

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Why is this study important?

Coronary computed tomography angiography (CCTA) is increasingly used in place of standard physiologic testing such as stress electrocardiography, stress echocardiography and myocardial perfusion imaging because it is non-invasive, fast, and can identify anatomic atherosclerotic disease. However, more “data” does not always translate to improved patient-oriented outcomes. This review and analysis explored whether CCTA is better for the patient.

Which, if any, threats to validity are most likely to have an impact on the results and how?

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