Is the combination of an anti-inflammatory drug with an opioid more effective for musculoskeletal injury pain in children than either agent alone?

BEEM Bottom Line

Why is this study important?

The optimal analgesic strategy for children with acute musculoskeletal (MSK) injury remains uncertain. Together with the removal of codeine from most hospital pediatric formularies, there is growing concern regarding the use of opioids in children. This study attempts to determine the best therapeutic agent in this clinical context.

Which, if any, threats to validity are most likely to have an impact on the results and how?

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