Is Ketamine effective at reducing pain over 120 minutes when used as an adjunct to opioid therapy?

BEEM Bottom Line

Why is this study important?

Given the opioid overuse crisis in North America and the possible risk of creating opioid dependence in the emergency department (ED), any opioid-sparing strategy to effectively treat pain is desirable. Ketamine has been shown to be a potentially useful analgesia that could have opioid-sparing utility in different ED pain settings.

Which, if any, threats to validity are most likely to have an impact on the results and how?

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