In patients with severe sepsis, does hydrocortisone prevent progression to septic shock?

BEEM Bottom Line

Why is this study important?

Glucocorticoids have an immunomodulatory effect that might impart benefit to those with sepsis. Although the mortality benefit of steroids has yet to be proven, current evidence suggests steroids can reverse septic shock. This randomized controlled trial (RCT) seeks to determine if hydrocortisone (HC) can prevent septic shock in patients with severe sepsis.

Which, if any, threats to validity are most likely to have an impact on the results and how?

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