Does oseltamivir within 48 hours of influenza symptom onset in children reduce the time to symptom resolution?

BEEM Bottom Line

Why is this study important?

Most efficacy data for oseltamivir comes from studies of adults, but in children and adults, oseltamivir is associated with modest reductions in the time to influenza symptom resolution albeit also with increased risk of vomiting.[1] [2] Given the burden of disease in children, a systematic review and individual patient data meta-analysis of randomized controlled trials (RCTs) in children was needed to determine the benefit and risks of oseltamivir.

Which, if any, threats to validity are most likely to have an impact on the results and how?

Thank you for your interest in the BEEM Journal!

To read the rest of this article or to access the entire collection of BEEM Critical Appraisals, please purchase a subscription at the link below.

If you would like a pre-view, click here to view some sample articles

Premium Content Available Through Subscription

BEEM is a knowledge translation project which aims to extract the most recent, EM relevant, and valid evidence from the volumes of available medical research and deliver it to EM practitioners in an easily consumable format to help guide their clinical practice. This valuable distilled information provided by BEEM is available through BEEM's accredited CME courses or through our online journal.

A BEEM Journal Subscription will provide you with unlimited access to our entire collection of Critical Appraisals for 1 year.