Does intravenous fluid infusion rate or composition affect neurologic outcomes in children with diabetic ketoacidosis?

BEEM Bottom Line

Why is this study important?

This is the first large randomized controlled trial (RCT) of children with diabetic ketoacidosis (DKA) to determine which fluid resuscitation strategy in terms of rate or composition can be definitively recommended as superior with respect to neurologic outcomes.

Which, if any, threats to validity are most likely to have an impact on the results and how?

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