Is penicillin V four times daily for five days as effective as three times daily for 10 days for group A streptococci pharyngotonsillitis?

BEEM Bottom Line

Why is this study important?

Group A streptococcal (GAS) pharyngitis is a common clinical problem for which the current United States and European guidelines for adults and children recommend penicillin V for 10 days.[1] [2] Reducing treatment duration to 5 days will decrease the total antibiotic (Abx) exposure and possibly improve compliance without negatively impacting clinical outcomes.

Which, if any, threats to validity are most likely to have an impact on the results and how?

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