Are prednisolone and/or low-dose dexamethasone noninferior to standard-dose dexamethasone for croup?

BEEM Bottom Line

Why is this study important?

Croup is a common childhood condition that causes significant burden to the healthcare system. Treatment of croup with a single dose of oral dexamethasone (0.6 mg/kg) has been shown to reduce symptom severity, rate of hospital admission, and return healthcare visits. This study tests whether a lower dose of dexamethasone (0.15 mg/kg), or alternatively, treatment with prednisolone are noninferior to the standard dose.

Which, if any, threats to validity are most likely to have an impact on the results and how?

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