How do NSAIDs compare with other oral analgesics for treating acute soft tissue injuries?

BEEM Bottom Line

Why is this study important?

Acute soft tissue injuries including sprains, strains, lacerations, contusions and hematomas are among the most common presenting complaints to emergency departments (EDs) worldwide. Pain is the most common symptom and the most common reason for oral analgesics including non-steroidal anti-inflammatory drugs (NSAIDs), acetaminophen (paracetamol) and opioids. NSAIDs are often favored as the analgesics of choice because of their combined analgesic and anti-inflammatory effects but are not without adverse effects. This systematic review and meta-analysis is an update of the summary evidence of analgesia and other outcomes associated with NSAIDs compared to opioids and acetaminophen.[1]

Which, if any, threats to validity are most likely to have an impact on the results and how?

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