Which are the most diagnostic features of infectious mononucleosis?

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Why is this study important?

A common pediatric complaint relates to fever, sore throat, and swollen or tender lymph nodes. This constellation of symptoms can have a variety of etiologies ranging from malignancy like leukemia to infections such as group A streptococcal (GAS) pharyngitis or infectious mononucleosis. The importance of differentiating between GAS pharyngitis and infectious mononucleosis involves the need for antibiotic treatment and associated beta-lactam exanthem and other adverse antibiotic effects of the former and the prolonged illness of the latter.

Which, if any, threats to validity are most likely to have an impact on the results and how?

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