Do patients with uncomplicated acute rhinosinusitis benefit from antibiotic treatment?

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Why is this study important?

Acute rhinosinusitis is an infection of the nasal passages and the paranasal sinuses, typically characterized by facial pain and nasal discharge lasting < 4 weeks. Despite its mostly viral etiology, antibiotics (Abx) are often prescribed for this infection. Whether or not Abx are prescribed, almost 1/2 of sufferers recover after 1 week and 2/3 recover after 2 weeks. This systematic review examines the net benefit of Abx treatment for uncomplicated acute rhinosinusitis.

Which, if any, threats to validity are most likely to have an impact on the results and how?

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