Is the combination of ibuprofen and acetaminophen for pediatric pain superior to either analgesic alone?

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Why is this study important?

Ibuprofen and acetaminophen are two of the three most commonly used analgesics in the world, along with opioid medications.[1] Given the current opioid crisis and unclear lifetime risks of opioid misuse after therapeutic use, determining ways to optimize pediatric pain management without opioids is of high importance for health practitioners caring for children. This trial compares the combination of oral ibuprofen and acetaminophen with each analgesic alone for pediatric emergency department (ED) patients with acute pain.

Which, if any, threats to validity are most likely to have an impact on the results and how?

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