What are the relative risks of stroke and bleeding in patients with paroxysmal versus sustained (persistent or permanent) atrial fibrillation who take oral anticoagulants?

BEEM Bottom Line

Why is this study important?

Atrial fibrillation (AF) is the most common cardiac arrhythmia seen in ED, and stroke risk and severity is markedly increased for these patients. Guidelines recommend use of oral anticoagulation therapy (OAT) based on the CHA2DS2VASc score for assessment of stroke risk irrespective of whether the pattern is paroxysmal or sustained.[1]

Which, if any, threats to validity are most likely to have an impact on the results and how?

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