What is the safety and effectiveness of non-invasive positive pressure ventilation compared to standard medical care for acute cardiogenic pulmonary edema?

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Why is this study important?

Acute cardiogenic pulmonary edema (ACPE) is one of the leading causes of admission to hospital worldwide and current guidelines differ in their recommendations for non-invasive positive pressure ventilation (NPPV) for this population. This 2019 systematic review and meta-analysis updates prior Cochrane reviews from 2013 and 2008.[1] [2]

Which, if any, threats to validity are most likely to have an impact on the results and how?

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