What is the effect of prednisolone in preschool children with wheeze associated with acute respiratory illness?

BEEM Bottom Line

Why is this study important?

The British Thoracic Society and others recommends a 3-day course of oral prednisolone for preschool children with moderate-severe wheeze.[1] However, wheezing in this population is impacted by different factors than in older children and adults and the recommended treatment with corticosteroids is controversial.[2]

Which, if any, threats to validity are most likely to have an impact on the results and how?

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