What are the frequency and associated short-term, adverse outcomes in high-risk patients of nonsteroidal anti-inflammatory drug prescriptions?
BEEM Bottom Line
Why is this study important?
There are limited analgesic options for older adults with musculoskeletal (MSK) pain, and it is well known that opioids are addictive and can impair cognition. Nonsteroidal anti-inflammatory drugs (NSAIDs) are commonly used to treat MSK pain in adults, but their use in high-risk older adults (i.e., those with hypertension [HTN], chronic kidney disease [CKD], or cardiovascular disease [CVD]) is discouraged. Even though NSAIDs are not recommended for high-risk patients, there is no strong evidence of renal or cardiovascular adverse effects from short term use.
Which, if any, threats to validity are most likely to have an impact on the results and how?
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