In adult patients requiring urgent reversal of warfarin, do prothrombin complex concentrates and fresh frozen plasma result in different rates of all-cause mortality?

BEEM Bottom Line

Why is this study important?

Patients with warfarin-associated major bleeding are seen frequently in the emergency department (ED). Consensus around optimal reversal strategy (vitamin K plus 1 of fresh frozen plasma [FFP] or prothrombin complex concentrates [PCC]) is lacking.

Which, if any, threats to validity are most likely to have an impact on the results and how?

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