What is the efficacy of amiodarone on survival after cardiac arrest compared to lidocaine or placebo?

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Why is this study important?

Until recently, the routine use of antiarrhythmics during resuscitation of refractory ventricular fibrillation (VF) and pulseless ventricular tachycardia (VT) patients was based on small randomized controlled trials (RCTs) evaluating short-term outcomes. This systematic review and meta-analysis (SRMA) summarizes the evidence for the use of amiodarone and lidocaine in out-of-hospital cardiac arrest, including a recent large randomized placebo-controlled trial.

Which, if any, threats to validity are most likely to have an impact on the results and how?

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