Does oseltamivir within 48 hours of influenza symptom onset in children reduce the time to symptom resolution?
BEEM Bottom Line
Why is this study important?
Most efficacy data for oseltamivir comes from studies of adults, but in children and adults, oseltamivir is associated with modest reductions in the time to influenza symptom resolution albeit also with increased risk of vomiting.[1] [2] Given the burden of disease in children, a systematic review and individual patient data meta-analysis of randomized controlled trials (RCTs) in children was needed to determine the benefit and risks of oseltamivir.
Which, if any, threats to validity are most likely to have an impact on the results and how?
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